LONDON: They may seem a fast and perfect way to remove those wrinkles, but a cosmetic surgeon is warning that thousands of women could end up with irreversible damage to facial tissue by opting for anti-wrinke injections.

French surgeon Dr Daniel Marchac said that he had based his conclusion after being consulted by 25 patients with irreversible damage to their subcutaneous tissue - the layer of fat underneath their skin - and their fibrous connective tissue.

He then asked 900 surgeons for more evidence on 'filler' jabs like Botox, and now carbon dioxide.

Based on what he has learnt, Dr Marchac believes that one in 20 people will be left with permanent damage by taking such injections.

These 'filler' jabs are of two types: One intended to be permanent and the other to be absorbed into the skin, and repeated after six months.

According to Dr Marchac from time to time these injections create serious problems.

"All of the permanent fillers are creating, from time to time, serious problems with bumps and deformities, and sometimes you have to operate," the Daily Mail quoted him, as saying.

"All serious plastic surgeons agree one should avoid permanent fillers. We will see in the future patients of 50 who have had 15 years of fillers, with fibrous, tough tissue we won't be able to do anything with.

"The serious things are the permanent fillers, and the second is abuse of resolvable fillers."

Dr Sherrell Aston, chairman of plastic surgery at Manhattan Eye, Ear and Throat Hospital, New York, said: "I am really concerned that in 15 years we will see a lot of people with lumps and bumps and no good way to treat it."