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News
Can't stop eating? Blame your genes

October 16, 2007
REUTERS

WASHINGTON: People who just can't stop eating may be able to blame their genes, at least in part, US researchers said on Monday.

They said up to 50 per cent of the population carries a gene variation that may give them extra pleasure from eating -- and may explain why they are willing to work twice as hard for snacks as the other half of the population.

The gene affects dopamine, an important message-carrying chemical, or neurotransmitter, associated with behaviour and movement.

"This gene is not just associated with overeating," said Jennifer Temple, a neuroscientist at the University at Buffalo in New York who worked on the study.

"It has been associated with drug addiction, alcohol abuse, gambling. It is associated with reward decisions," Temple added in a telephone interview.

Writing in the journal Behavioral Neuroscience, Temple and colleagues described an experiment in which they gave people access to many tasty snacks, including chips and chocolate.

Their volunteers thought they were taste-testing the food, but Temple's team watched to see who ate the most.

They also ran genetic tests on their 74 unwitting volunteers, looking for variations in two genes that affect dopamine levels.

One gene appeared to have no effect on eating. But the Taq1 A1 variation had a noticeable effect. People carry two copies of each gene, one from the mother and one from the father.

Nearly half the population has one A1 and one A2 version, while the other half has two copies of A2. It is rare for someone to have two A1s.

People with two A2s experience feelings of reward easily, while people with A1 may have to work harder to feel good, the researchers said.