NEW YORK: Recordings from electrodes in the human brain may offer the first objective way to measure the intensity of pain, a media report said on Friday.

Nature quotes researchers as saying that they have found a neural signal that correlates with the amount of pain that an individual feels. The signal could be used to refine pain-relief techniques that involve stimulating the brain with electricity.

Single cells, the report says, have previously been identified in the human brain that are active in pain, but their response is binary, signaling either pain or no pain.

Now Nature says Morten Kringelbach of the psychiatry department at the University of Oxford, UK, and his colleagues have identified low-frequency brain waves that emanate from two regions buried deep within the brain when a patient is in pain.

The more pain that is experienced, the longer the waves last. Kringelbach's team, the report says, recorded activity from two electrodes positioned in the thalamus and the periaqueductal grey area of 12 awake people who had been undergoing deep-brain stimulation (DBS) for chronic pain.

During the recording, the team touched either a painful or pain-free area of the patients' bodies and had patients rate their pain every minute. The duration of the waves dubbed "pain spindles" correlated with how intensely the patients felt their pain.

"It is an objective measure that correlates with a subjective measure," Kringelbach, who presented the findings at the Society for Neuroscience meeting in San Diego, California, last week, was quoted as saying.

This signal could help refine DBS for such patients, he says. Currently, the electrodes fire signals continuously, even when the patient doesn't need pain relief, which wears down the implanted battery. "We could have a stimulator that picks up this neural signature of pain and only starts sending signals at that point," Kringelbach says.

"It would be great to have a 'signature of pain'," Allan Basbaum, a neuroscientist at the University of California, San Francisco, was quoted as saying.

The next step is to try to record the signals with a non-invasive technique, such as magnetoencephalography, which measures electrical activity in the brain via changes in the magnetic field, Nature says. This could allow pain monitoring in a much broader range of patients.